À Votre Santé!
I am a wine buff. Several years ago I did a one year training with the Wine and Spirit Education Trust which turned me from a dilettante to someone who knew how to understand the subtlety of wines from one end of a vineyard or another. Oh yes, and how to get very good wine for not many $$.
I also learned a whole range of other new skills. Ever since then I’ve been interested in the health consequences of drinking wine. Of course, too much of a good thing isn’t. But there has been so much evidence that certain types of wine, when used in moderation, can do wonderful things for your health.
This week has seen the publications of a paper in the journal Nature, that has been described by Steve Bloom from the Imperial College Faculty of Medicine like this: “It could be the breakthrough of the year, with massive possibilities for treating human beings.”
Steve is not given to hyerbole, so what has got him so passionate?
The answer is that a chemical found in dark grapes and in red wine called resveratrol, that could make guilt-free gluttony a reality.
Why is this?
Previous research has revealed the substance has anti-ageing effects in some organisms, extending the lifespan of yeast by 60%, worms and flies by 30%, and fish by about 60%.
It has also been suggested the reported health benefits of red wine may also be due to resveratrol.
When given to mice, it countered some effects of a high-calorie diet, with 60% of the calories coming from fat, improving their health and increasing their life-span. The mice showed decreased glucose levels, healthier hearts and liver tissue, and better motor function compared with the mice on the same diet but without the supplement.The chemical could not reverse all consequences of overeating – the mice did not lose any weight.
The researchers also discovered that the chemical was extending the mice’s life-span. The scientists estimated resveratrol reduced the risk of death in the mice by about 31%. After six months, resveratrol essentially prevented most of the negative effects of the high calorie diet in mice.
The exact mechanism of the chemical is not yet known, but the researchers believe it may be activating a gene called SIRT1, which is linked to a family of proteins thought to be involved with longevity.
This is not yet an invitation to enjoy limitless quatities of grapes or wine: a glass of red wine has only 0.3% of the relative resveratrol dose given to the gluttonous mice.
BTW, you may be interested to know that Nature is now providing an excellent podcast based on papers in this week’s edition.
DHEA: Hype, Hope and Disappointment
Dehydroepiandrosterone (DHEA) is a hormone that has attracted a lot of attention. It’s launched hundreds of websites, product lines and a few books and magazine articles. So what’s all the fuss about, and should we all be chomping down on DHEA tablets?
DHEA is manufactured at several sites in the body, but by far the most important is in one of the outer layers of the adrenal gland. Like all the steroid hormones it is made from cholesterol. It has various protective effects in the body, regulates some enzyme systems, can be converted to estrogen and under certain circumstances to testosterone. It has very weak androgen (male hormone) activity.
In cell culture it has a lot of other actions too, but it is always difficult to jump from effects seen using large doses in isolated cells, to giving advice on what supplements people should be taking.
There has been a lot of talk about the possibility that some people may, as a result of stress or toxins, suffer from exhaustion of the adrenal glands. There is a great long list of symptoms that may be caused by this so-called adrenal fatigue, deficiency or insufficiency: the terms are often – and incorrectly – used interchangeably. And therein lies the problem. It is such a long list that it is non-specific. It’s always a bit of a worry when someone tells me that dozens of different symptoms are all caused by one single biochemical problem. That just isn’t the way that the human body works.
I have seen and treated countless people with a condition known as Addison’s disease: true chronic adrenal insufficiency. It can be a very serious illness and it is quite different from the “adrenal fatigue” that people talk about in some popular books. People with chronic fatigue syndrome do have lower levels of activity in what is known as the hypothalamic-pituitary-adrenal axis, but it is not because the adrenal glands are not working properly, but because the hypothalamus in the brain is not doing it’s job properly. There’s also no proven link between “burnout” and adrenal function.
During my years as an endocrinologist and holistic physician, I’ve spent a great deal of time looking for adrenal fatigue in sick people and I’ve never found it. I’ve done all the tests recommended by proponents of adrenal fatigue and adrenal insufficiency and when we’ve done the tests properly, we’ve drawn a blank. There are a great many parallels between the adrenal insufficiency story, and the old – and discredited – myth about people becoming unwell because of a thyroid deficiency that cannot be picked up on standard thyroid function tests.
So can DHEA do you any good? Or can it be harmful? What exactly is the evidence?
- There is a comprehensive study, called The Dehydroepiandrosterone And WellNess (DAWN) study that should give us some solid answers as to the risks and benefits of DHEA. I shall post details of the findings as they become available. But some things we know already:
- DHEA has been touted as an anti-aging supplement. But in a two-year prospective study done in older people attending the Mayo Clinic in Rochester, Minnesota, neither DHEA nor low-dose testosterone replacement had physiologically relevant beneficial effects on body composition, physical performance, insulin sensitivity, or quality of life. Perhaps the people in the study didn’t get enough DHEA, but it doesn’t look that way. Instead it seems that just giving the supplement doesn’t seem to do very much. But there is increasing evidence that 50-100mg of DHEA each day will improve muscle strength and muscle mass in older people who are doing strength training. Once again, it does nothing in people who are not exercising. Sorry!
- According to the results of a small placebo-controlled, randomized trial published in the Archives of General Psychiatry, DHEA can be effective for midlife-onset minor and major depression. The study was conducted the National Institute of Mental Health Midlife Outpatient Clinic. In the trial, 23 men and 23 women aged 45 to 65 years with midlife-onset major or minor depression were randomized to six weeks of DHEA therapy, 90 mg/day, for three weeks and 450 mg/day for three weeks or to six weeks of placebo followed by six weeks of the other treatment. The subjects did not receive any other antidepressant medications during the study. Both of the doses of DHEA helped improve depression: there was no advantage in going to a higher dose, and there was no difference in the treatment response of men and women. The trouble with this study was not just the small size and the short duration, but the DHEA was not compared against a standard antidepressant. So we are still in the dark as to how effective it really is. It’s nice that it’s better than placebo, but this is just the first step in a larger research program.
- A study from Taiwan indicated that people with higher levels of DHEA sulfate had a lower overall mortality over a three-year period. That is interesting, but absolutely does NOT mean that artificially increasing our levels of DHEA with supplements will make us live forever: we don’t yet have that kind of magic bullet.
- In mice, quite large amounts of DHEA have the effect of slightly reducing the normal increase in stiffness of the left ventricle that can happen as animals get older. We have no idea whether something similar might help in humans, and the amounts of DHEA involved may rule it out as a viable treatment in people.
- 50mg/day improves subjective wellness in people who have no active pituitary gland. A rare condition, and we cannot use this evidence to advise healthy people about what to take.
- Because DHEA is converted into estrogen and/or testosterone, it may have the potential to exacerbate or initiate hormone-responsive tumors. The evidence is not strong one way or the other, but it remains a worry. I don’t think that anyone recommends DHEA to people who have a personal or family history of breast or prostate cancer.
There is a BIG literature on DHEA. But my current conclusions from all this?
- 50-100mg of DHEA is probably worth trying if you are over 50 years of age and doing regular exercise.
- It may help a bit with mild depression.
- It should not be used in people with a personal or family history of breast, prostate or any other type of hormone-sensitive cancer.
Aging, Skin and Cancer
There’s a very interesting paper in this month’s issue of the journal Developmental Cell, based on research conducted at the Oregon Health & Science University in Portland, Baylor College of Medicine in Houston and Leiden in the Netherlands.
The investigators have found a pathway through which a gene’s over-expression causes stem cells in the skin to switch from creating hair follicles to creating sebaceous glands. This discovery may not only provide us with new ways of treating hair loss and oily skin, but it may help us to prevent and treat some cancers.
Skin cells turn over very quickly: just think how fast a graze gets covered over. Epidermal stem cells give rise to the outer layer of the skin that serves as a barrier for the body, as well as generating the follicles that produce hairs and sebaceous glands. These glands produce oils to lubricate the skin. In aged skin, a protein called Smad7 is overproduced, which triggers hair loss and sebaceous gland growth.
This is the first study definitively to link Smad7 over-expression and the pathological changes that occur in aged skin.
Here’s the twist: Smad7 shuts down signaling of another group of genes called Wnt. It binds to a Wnt signaling protein known as Beta-catenin and degrades it with an enzyme called Smurf2. (I don’t known why they decided to call it’s call it Smurf: it looks like ponderous chemical humor to me!) Wnt signaling is critical for organ development, but if Wnt signaling is too active, it also causes cancer.
Enhanced Beta-catenin signaling contributes to many types of cancer, including colon, lung and brain. Perhaps inducing over-expression of Smad7 or delivery of Smad7 directly to tumor cells would provide a therapeutic approach because of the boost in Beta-catenin degradation.
And finally, impaired Beta-catenin signaling contributes to neurodegeneration, such as that found in Alzheimer’s and Parkinson’s diseases, retinal degeneration, some bone density defects and aging. For these diseases, blocking Smad7-mediated Beta-catenin degradation may offer a therapeutic approach.
Blueberries
One of the principles of integrated medicine is that anything that’s good for you should have more than one benefit. So omega-3 fatty acids may help with cardiovascular health, mood, memory, attention deficit disorder, as well as the health of skin and bones.
Another one is the blueberry. I’ve been sufficiently impressed by the data on the health benefits of blueberries to have been a regular grower and consumer for years. They contain a number of potentially healthful compounds including polyphenols and anthocyanins, which can help modulate and balance the free radical systems of the body. Remember what I said recently about the value of keeping some free radicals in the body? The last thing that we want to do is to be rid of all of them!
There is reasonably good evidence that regularly eating blueberries can support cardiovascular health and there have been suggestions that they may reduce the risk and aggression of cancers of the prostate and colon.
There is also some evidence in animals that some of the components of blueberries may reduce inflammation and the effects of strokes – interruptions to the blood flow in the brain.
As a consumer, I’ve been carefully watching the growing evidence indicating that blueberries – or some of their constituents may have effects on animal cognition, brain aging and the normal neuroprotective mechanisms in the hippocampal region of the brain.
We do not yet have proof that these same effects occur in humans, and there are always three questions when we look at nutritional data:
- Can we extrapolate from the animal to humans? Mice are not men
- Are the amounts of blueberries or blueberry extracts even close to what humans could consume without spending all day eating, or getting a terribly upset intestine? There have been countless reports of the benefits of supplements that had to be taken in the most enormous doses to do any good. I’ve mentioned before the problem of L-arginine, which is sold as a “Natural Viagra.” Except that you need to take around nine grams for it to do much good, and most supplements contain less than a tenth of that. Regular readers will also remember my report concerning an article on coffee and sex. It was said that coffee would raise a woman’s libido. And indeed it does, if she drinks at least ten large cups of coffee at once. And coffee is a marvelous diuretic.
- When extracts are used, are we sure that we are getting the correct ingredient of the fruit? Many beneficial fruits contain just the right combination of nutrients to help us, so each can be taken in a small dosage or concentration. As with so much in integrated medicine, combinations are key. Take out one extract of a fruit, and you may lose the clinical effect that you wanted.
All that being said, the evidence is becoming progressively more interesting, and there is enough suggestive evidence for me to keep packing away the blueberries.
And just to show that I leave no stone unturned when checking the literature on your behalf, I rejoiced to learn that supplementing the diet of Arctic char with various supplements – including blueberries – improved the quality of his, ahem, semen. I do not know how this information will help any of us yet. Neither do I really know why a fish would want to eat blueberries or any of the other supplements that they were tried on. Though I’m sure that people have often asked similar off the wall questions about some of my research….
Free Radicals, Aging and Small Hairless Creatures
I’m accused of many things.
Apart from the oft-repeated falsehood that I was the inspiration for Hugh Laurie’s brilliant characterization of the cranky Dr. Gregory House (I definitely was not!), I have been accused of having a fixation with mole rats. Well, that one is partly true: they are fascinating little creatures.
But let me start at the beginning. Over the last three decades, free radicals have entered the national vocabulary. In the 1983 James Bond movie, Never Say Never Again Edward Fox orders Sean Connery to enroll in a health clinic in order to "eliminate all those free radicals."
Free radicals are found in nature: they can be derived from combustion and some other chemical reactions and they are generated in the atmosphere by the action of ultraviolet radiation with chlorofluorocarbons. But most found in the human body don’t come from the environment: they are generated by biological processes. The majority are extremely short lived, but a few special types can hang around for hours.
An excess of free radicals has been linked to an array of illnesses, including:
Some cancers
Diabetic vascular disease
Parkinson’s disease
Schizophrenia
Alzheimer’s disease
Emphysema
Age-related changes in the skin
Macular degeneration
This list just names a few: many other illnesses have been laid at the door of free radicals. You will often see people talking about “oxidative stress,” to describe the damage done by an excess of free radicals. There is a theory that normal aging may be a result of the gradual increase in the production of free radicals in the body
There is something to all this: I did some research on the role of free radicals in diabetic vascular disease in the 1980s, and made some interesting discoveries. It has recently been shown that an excess of free radicals in the wrong place can play a part in generating insulin resistance.
The trouble – as with so many apparently simple ideas – is that many of the popular concepts about free radicals are over-stated or even wrong.
We first have to ask ourselves, “If free radicals are so bad, then why does the body produce them at all?”
The answer is that free radicals play a crucial role in a number of important biological processes, including the killing of bacteria by a group of white cells known as granulocytes. They are also thought to be key cancer killers and prime mediators of normal communication between cells.
Yet they have been pilloried: thought to be the key to so many illnesses when, in fact, they are intimately involved in normal biological processes: if you had no free radicals you would probably die quickly and unpleasantly. We know that because there is a group of rare, fatal illnesses in which children cannot generate free radicals.
Rather than focusing on ways to eliminate free radicals, we should be dealing with ways to balance them.
Our bodies are loaded with sets of enzymes whose task is to mop up excessive numbers of free radicals. The most important of these are superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase.
When you see an advert or article extolling the virtues of some product because it abolishes free radicals or “reactive oxygen,” you know that you are dealing with some nonsensical marketing. Not science.
Fortunately, despite the marketing hype, it’s virtually impossible to obliterate all the free radicals in your body: Some must remain in your system or you will run into all kinds of medical problems.
Let me give you two examples of research that has shown first the good side of a producer of free radicals and second, one of the reasons why we know that there is more to aging than free radicals.
A study from France looked at a dye called mangafodipir that is used in MRI scanning. It was found to increase the cancer-killing ability of some chemotherapy drugs, while at the same time protecting normal cells. Mangafodipir was found to help promote the production of hydrogen peroxide while at the same time, through different biological mechanisms, protecting healthy cells from damage.
The second piece of research concerns my mole rats. I’ve talked about them before. They are extremely long lived: most reach the age of 25-30. And they seem never to get cancer. There are very few species that are spared from cancer: sharks rarely get the disease and there are some simpler organisms that also seem to be spared. So these mole rats have attracted the attention of researchers. What is more, they have very high levels of DNA damaged by oxidation so by rights they should get cancer and age prematurely. The fact that they don’t is leading to a whole new line of thinking about aging and illness.
So the message should be this: oxidative stress may be a factor in illness and aging, but your aim should be to modulate the free radical systems in your body, not to obliterate a key cancer killer.
Eat a diet that is rich in antioxidants
Don’t try and avoid stress: you can’t. Learn to manage it
Take regular physical exercise
Avoid environmental toxins such as smoke, excess sunlight, pesticides and radiation
A New Way of Looking at – and Treating – Inflammation
Diseases of both large and small blood vessels are two of the biggest problem facing people with diabetes. Not only is it a huge clinical challenge, but also nature sometimes does our experiments for us. The high rates of coronary and peripheral vascular disease in diabetes can be seen as a kind of experiment of nature: a recognizable set of chemical abnormalities that might shed light on vascular diseases in general. It was those twin factors: a huge clinical problem, and an experiment of nature, that lead me to pick the topic of my research doctorate.
When I was working on my research doctorate in the mid 1980s, I came across a lot of old research that seemed to show links between inflammatory and autoimmune conditions like systemic lupus erythematosus and rheumatic fever, and the eventual development of coronary artery disease. There was also a lot of old and largely forgotten research about the link between some viral infections and the development of coronary artery disease and acute coronary artery occlusions, because some infections can make blood more “sticky.” Inflammation evolved as one of the body’s defence mechanisms.
So I made the proposal – revolutionary at the time – that diabetes, coronary artery disease and a range of other illnesses might be inflammatory rather than degenerative. I soon found inflammatory markers in people with diabetes, that helped predict when someone was running into trouble with their eyes, kidneys or heart. Even with stacks of data, I had to spend a lot of time defending that position, because it also implied that some illnesses thought to be irreversible might not be.
With the passage of time, it has tuned out that I was probably correct. Chronic inflammation, wherever it starts, mat have long-term effects on the body and on the mind. Chronic inflammation increases the risk of diseases of many blood vessels, as well as causing anemia, organic depression and cognitive impairment. Here is a partial list of common conditions in which inflammation is a prominent factor:
1. Rheumatoid arthritis
2. Systemic lupus erythematosus
3. Fibromyalgia
4. Chronic infections
5. Insulin resistance or metabolic syndrome
6. Arteriosclerosis
7. Diabetes mellitus
8. Hypertension
9. Asthma
10. Inflammatory bowel disease
11. Psoriasis
12. Migraine
13. Peripheral neuropathy
14. Alzheimer’s disease
15. Autism
16. Gingivitis
17. Cystitis
The reason for raising the issue is not to say “told you so!”
It is instead that we need to think about inflammation a little differently. There is a mountain of information about the physical aspects of inflammation. We can stop at the simple description of inflammation as a condition in which part of the body becomes reddened, swollen, hot, and usually painful, or we can look below the surface: we can examine inflammation not only as a physical problem, but also as a psychological, social, subtle and spiritual problem. Why bother? Because the deeper approach allows us to understand and to treat and transcend inflammation as never before.
I am going to write some more about specific ways to address inflammation and what it means in future articles. I would also like to direct you to the book Healing, Meaning and Purpose, in which I talk about specific approaches in more detail.
But I would like to start with this.
In Ayurvedic and homeopathic medicine, inflammation is a sign of an imbalance in the vital forces of the body, and the traditional Chinese system agrees: here inflammation is usually a manifestation of an excess of Yang Qi, or a deficiency of Yin Qi. Most of our lives are seriously out of balance: Yang Qi is like a rampaging lion that has been stimulated by:
Acidic foods;
Environmental toxins;
Unwanted sexual stimulation:
Noise;
Discordant music:
Constant demands from others:
Toxic relationships;
Years spent in front of television sets and limitless multi-tasking.
It should be no surprise to learn that all of these inflammatory conditions are increasing rapidly throughout the Western world. Not because we are getting better at identifying them, or we are living longer, but genuinely increasing.
It is wrong to put all the blame on poor diets or inadequate exercise. The problem is more subtle and is a reflection of distorted Information being fed to our bodies, minds, relationships, subtle systems and spiritual relationships.
The great news is that this simple conceptual shift gives us a whole load of new tools for handling these problems, and for using them as catalysts to growth.
In the next few weeks, I am going to drill down and give you some specific guidance that ties into the material in Healing, Meaning and Purpose and the next two that are on the launch pad.
Fasten your seat belt!
Technorati tags: Inflammation Aging Alzheimer’s disease Arteriosclerosis Neuropathy Autism Arthritis Systemic lupus erythrmatosus Fibromyalgia Inflammatory bowel disease Gingivitis
Add Years to Your Life and Life to Your Years: The Power of Small Changes.
I want to tell you about a mind bogglingly important study that many professionals have known about, but somehow hasn’t popped up on most people’s radar. The story was broken by the BBC last month. It is about an exceptionally important study that has been running in Norfolk, in Eastern England, as well as other parts of Europe since 1992. The British section is directed by Professor Kay-Tee Khaw who is Professor of Clinical Gerontology at the Department of Public Health and Primary Care at the University of Cambridge. The main focus of the Clinical Gerontology Unit is the maintenance of health in aging populations, with a particular emphasis on the combined role of lifestyle, environmental and genetic factors in chronic diseases.
The UK arm of the study has been following 25,663 men and women aged between 45 and 79 years old, looking at their diet, environment, lifestyle and health. The latest results from the study have confirmed several things that we already suspected: 1. Eating five portions of fruit and vegetables a day can give you the life expectancy of someone three years younger.
2. Not smoking turns back the clock by four to five years.
3. Even increasing exercise by a moderate amount can increase your life expectancy by three years. But the amount of exercise someone would need to do to achieve that depends on their job. A sedentary office worker would need to do one hour of exercise, such as swimming or jogging every day. By contrast, a person with a moderately active job, such as a hairdresser, would need to take 30 minutes of exercise a day. Here’s some more good news: People with very active jobs, including nurses and bricklayers, do not need to do any extra exercise – as their work is strenuous enough.
I think that just about anyone can take those baby steps toward a longer and healthier life
There’s an old Yugoslavian Proverb:
“Grain by grain a loaf, stone by stone, a castle.”
That seems about right!
Technorati tags: Health Longevity Preventative medicine Wellness
The Status Syndrome
I have recently seen some reports in the media about a connection between money and longevity: the idea being that the more money you have, the longer you live. Which presumably means that Bill Gates will live forever. Sadly this link between wealth and longevity is a false extrapolation from some very old research. Yes, extreme poverty is associated with excess mortality, not only because of poor lifestyle and lack of access to medical screening and care, but also because adults who were of low birth weight are more likely to develop diabetes and hypertension. And people born into poverty are more likely to have been malnourished before birth, and therefore to be of low weight at birth. This relationship between low birth weight and subsequent disease is likely the result of incomplete development of the liver and kidneys before birth.
A famous study of British civil servants has indeed shown that people who work in more senior positions are more likely to live longer than people working in the lower ranks. But it has nothing to do with money. Once people have passed a certain critical material threshold, lifestyle factors have progressively less impact. There are still more smokers amongst manual workers and hours of hard work means that they have to eat high calorie high fat foods to be able t keep working, and we have not done a good job of showing people how easy it is to eat healthily on a budget.
Sir Michael Marmot is an outstanding epidemiologist working in London, who has spent three decades examining the health consequences of differences in social standing. He has discovered that there is a social gradient that predicts health outcomes: the lower a person’s social rank, the higher their risk for heart disease, diabetes, mental illness, accidents and many other health problems. Once people have passed a certain threshold of physical and material well-being, something else comes into play: other kinds of well-being that have a massive impact upon life. These are autonomy – how much control you have over your life – and opportunities for social engagement and participation. The psychological experience of inequality has profound effects on multiple body systems. Sir Michael has summarized a lot of his research in an eminently readable book entitled, appropriately, The Status Syndrome.
There is an interesting corollary of the Status Syndrome. In his book The Pecking Order, Dalton Conley presents interesting research that indicates that our level of success relative to our siblings is less the result of birth order or genetics and more the result how much family resources – time, energy, money and love – we received while growing up.
There’s not much that you can do about your birth order, but all this research has some important implications.
1. Once you have crossed a threshold that allows you access to nutritious food, exercise, stress management and health care, there is no longer any link between health and wealth. In fact, working and working to get more and more money is associated with increased mortality!
2. The amount of time, energy, money and love that the family is able to give to each child will help shape and structure their future life. That is a hugely important responsibility.
3. Ensure that you feel and know that you are autonomous: that you are in control of your life. I really urge you to work on this. One of the reasons for being concerned about the ever-increasing demands being made upon all of us is that it can make us feel out of control. I spend a great deal of time in Healing, Meaning and Purpose discussing and demonstrating techniques for taking back control of your life.
4. Are you socially engaged and participating in life? Are you doing something for your community or your church? How often do you meet new people and engage with them? Is there someone whom you haven’t seen for a while that really needs a call from you? Please do think about this: it’s not just about socializing; it’s about protecting your health and well-being, and the health and well-being of those around you.
Technorati tags: status syndrome, Michael Marmot
Integrated Health and Aging
An important principle of the emerging laws of health and healing is that anything helpful should help more than one system of the body at a time. So a diet that might help mitigate the effects of aging in the skin should also have beneficial effects on the major organs of the body.
So I was encouraged to see a new report indicating that cardiovascular health and a healthy lifestyle are associated with maintaining the health of our brains as we age. This is, of course, intuitively obvious, but it is always nice to see such things confirmed by empirical research.
The new report is from a multi-Institute collaboration of the National Institutes of Health (NIH) published online in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. The chair of the committee was Hugh Hendrie, the Scottish-born professor of psychiatry from the University of Indiana, and the committee members were many of the most eminent people in the fields of aging and Alzheimer’s disease.
What is encouraging about this new report is that many of the factors associated with cognitive decline as we get older are eminently remediable: we have within our reach a set of potential interventions that could significantly reduce our personal risk of developing cognitive problems later in life. These are the things that we need to work on if we want to reduce our risk of developing cognitive decline later in life:
- Hypertension: There is excellent evidence that inadequately treated hypertension correlates strongly with cognitive decline.
- Physical activity: There is good evidence that elders who exercise regularly are less likely to experience cognitive decline. This is over and above the general improvement in quality of life that accompanies regular exercise. The earlier in life that we start, the easier it is to continue.
- Increased mental activity throughout life, including learning new things and going through higher education may benefit the health of the brain.
- Moderate alcohol use and the use of vitamin supplements also seem to be brain protectors, though the report does not specify which supplements.
- Social disengagement and depressed mood are both associated with poorer cognitive functioning, so it is important to be alert to signs of depression, and to maintain a social network. I discuss this in more detail in my book Healing Meaning and Purpose.
There are doubtless some genetic and environmental factors about which we can do little. But the idea that we now have a list of things that we can do to protect our brains is very exciting.
This report also signals another important change. In recent years we have seen the growth of Positive Psychology, the study of how to improve ourselves rather than the constant focus on psychopathology. This report calls for the research community to study health maintenance of the brain with the same energy that it has brought to bear on the study of diseases of the brain. To which I would add, that we must not just focus on how to maintain the health of the brain, but how we can enhance it’s function so that we can all reach and exceed our full potential.
Technorati tags: aging, Integrated health, Positive Psychology, healthy lifestyle,
A Rainy Day Question
“Millions long for immortality who do not know what to do on a rainy Sunday afternoon.”—Susan Ertz (a.k.a. J.R. McCrindle, Anglo-American Novelist, 1894-1985)
It is widely known in the scientific community that there has been a great deal of progress on aging research, much of it done behind the closed doors of pharmaceutical companies. According to Professor Tuljapurkar between 2010 and 2030, the modal, or most common, age of death will increase by 20 years if anti-aging therapies come into widespread use. This projected increase is based on some sophisticated modeling, and reflects a life-span growth rate that is five times faster than the current rate. If accurate, this would increase the modal age of death in industrialized countries such as the United States from roughly 80 years to 100.
So back to the question: if you suddenly discovered that you were going to have an extra thirty years of healthy life, what would you do with it?
I really do suggest that you start thinking about that. Assuming that you have enough money to live a decent life, what would you do with that extra twenty years? Would you:
1. Enjoy spending more time with younger members of the family?
2. Learn some new skills?
3. Make new friends?
4. Travel?
5. Read those books you always meant to?
6. Become more involved in spiritual pursuits?
7. Find a new way of serving others?
8. Sit in front of the television?
What plans or aspirations do you have that you want to add to this list?
But then I have another question for you: if your answers included any of the points from 1-7, why not do them right now? What exactly is stopping you from doing all those things today?
