Richard G. Petty, MD

Growth Hormones and Intelligence

A team of scientists from the University of Bristol in the United Kingdom has published research that seems to show a link between the hormone insulin-like growth factor 1 (IGF-1) and a child’s IQ. IGF-1 has been a big interest of mine for many years. It’s production is primarily stimulated by growth hormone, particularly in the liver. At one time it was known as somatomedin. But IGF-1 is also produced and has important actions in the brain. The production of IGF-1 falls dramatically when people are malnourished, and it has been suggested that one of the primary problems in Alzheimer’s disease is malnutrition that then causes a fall in IGF-1 levels in the brain.

It has long been known that babies of low birth weight develop more slowly, and that shorter children often do worse in school. It was always assumed that their poor performance in school was because they were picked on or bullied, or because they felt the need to compensate for their height in some way. But it may be that there is also a physical component to this association between height and intelligence.

The researchers examined 547 children who completed and intelligence test at the age of eight. At the same time they measured the circulating levels of IGF-1 in their blood. They found a link between higher levels of IGF-1 and higher IQ. This study will be the first of many, but it provides some preliminary evidence that IGF-1 plays an important role in the development of the human brain, and may underlie the associations between birth weight, height and IQ.

A study from Holland provides further support for this link: 74 low birth-weight children were treated with growth hormone and followed up over two years. Not only did the children grow, but also their intelligence increased.

This work is also important because it shows one of the likely results of malnutrition is an impairment in the development of the brain.

Would there be any point in adults taking growth hormone to improve brain function? Despite the claims made in some popular books, the answer to that one is probably no. We know a great deal about the consequences of hyper-secretion of growth hormone in adults: it occurs in several illnesses, the most common is called acromegaly. Intelligence has not been examined systematically in people with acromegaly, but after seeing a great many people suffering from the condition, unusually high intelligence has not often been a feature. And there has been research on measuring IQ after giving growth hormone to people with an array of medical conditions. It only seems to help people who are actually deficient in the hormone.

And I’d just like to point out that the association between height, achievement in school and success in life is quite weak. Think Napoleon Bonaparte and Alexander the Great.

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Black Cohosh for Menopausal Symptoms

Black Cohosh (Actaea racemosa or Cimicifuga racemosa) is a commonly used herb also known as baneberry, black snakeroot, bugbane, squawroot, rattle root. It is most often prescribed for the treatment of symptoms related to menopause. As with many herbs, the purity and constituents of most Black Cohosh products has generally not been well established.

There are three major active constituents of Black Cohosh:
Triterpene glycosides,
Phenolic constituents, and
Formononetin

The May 17 issue of the Journal of Agricultural & Food Chemistry reported that of 11 Black Cohosh products analyzed for these three constituents, 3 only contained an Asian adulterant (Asian Actaea) instead of Black Cohosh, and 1 contained both genuine Black Cohosh and Asian Actaea. For the products containing only Black Cohosh, there was significant product-to-product variability in levels of the selected triterpene glycosides and phenolic constituents and no formononetin was detected at all.

The way in which Black Cohosh is thought to work is by reducing the levels of luteinizing hormone (LH) and modulating estrogen. LH is a pituitary hormone that stimulates the ovary to produce estrogen and testosterone. As estrogen levels fall, the pituitary responds by increasing its production of LH. And the increasing levels of LH are implicated in the production of some menopausal symptoms. The Black Cohosh binds to the estrogen receptor, reducing the production of LH. Therefore by reducing LH, Black Cohosh reduces the production of estrogen that is responsible for some menopausal symptoms. It is useful to know this: three days ago I was asked to consult on the treatment of a woman who had her ovaries removed, was on hormone replacement therapy, but was taking Black Cohosh for menopausal symptoms. It had not helped her, which was not surprising: the evidence shows that you need at least one ovary for it to work.

I would also like to mention a program for professionals that I wrote late last year. It is available here. Although designed for health care professionals, it is one of the most comprehensive and up to date reviews on the uses, side effects and interactions of over twenty of the most commonly used herbal remedies. There is also a detailed discussion of how to work out if a remedy is likely to interact with prescription medicines and a comprehensive set of resources: scientific references, books and websites, together with advice on obtaining effective herbs.

Oh yes, and some really nice pictures of all the herbs that I discussed!

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Migraine and Hormones

Migraine (can be a frightfully difficult problem to treat. It is such an interesting puzzle, that the first book that I ever wrote was on migraine and other types of headache. Migraine is a great deal more than just a severe headache. It is can also be associated with neurological symptoms, and people often become exquisitely sensitive to light and sound. Additionally, at the beginning of the attack, the stomach stops working properly, which can make the absorption of medicines very difficult. Then comes the vomiting and sometimes diarrhea.

Although migraine is usually described as a “vascular” headache, there are strong reasons for thinking that it is more than that. People who suffer from the classic type of migraine often have spreading visual problems or partial visual loss, which goes on for between ten and sixty minutes. These visual problems are likely the result of a spreading wave of neurological depression spreading over the visual cortex at the back of the brain. The sensitivity to light and sound suggests that something is going wrong in the neurological systems that normally filter sensations, and the gastrointestinal problems indicate that something is going wrong in some of the control centers of the brain. There are some real oddities about migraine: it is exceptionally uncommon in people with diabetes; appears to be slightly more common in people who are left handed and is one of the only illnesses that tends to gets better as we get older.

There are a number of well-known triggers to migraine attacks. Though the scientific literature on triggers is not conclusive, here are some of the more common ones, that if avoided, have helped a great many people:

  • Stress (either during stress, or when the pressure comes off)
  • Cheese
  • Chocolate
  • Coffee
  • Citrus fruit
  • Red wine
  • Changes in the weather (especially when there are a lot of positive ions in the atmosphere)
  • Mono-sodium glutamate (MSG)

One of the best-known features of migraine is that it is considerably more common in women and that there is often a relationship between headaches and phases of the menstrual cycle, in particular during the pre-menstrual days. There have been many small studies that have indicated that oral contraceptives might increase the risk of suffering from migraine. A new study from Trondheim in Norway, has confirmed a link between oral contraceptive and migraine. The Nord-Trøndelag Health Study was done between 1995 and 1997. It included 14,353 pre-menopausal women, of whom 13,944 (97%) responded to questions regarding their use of contraceptives. There was a significant association between migrainous and non-migrainous headaches and the women’s reported use of estrogen-containing oral contraceptives. An important finding was that there was no relationship between the number of headaches and the amount of estrogen in the contraceptive pill.

There is one more thing to factor into the equation. Over the last two decades, there have been many reports of an association between certain types of migraine and cerebrovascular accidents (“strokes”). In the largest analysis of the data, that was published in the British Medical Journal, there was indeed a higher rate of strokes in women who had migraine and who were taking oral contraceptives. These studies included some of the older ones done in the days when the doses of hormones were higher than they are today, but when making decisions, it is important to be aware of this rare association.

An editorial in the British Medical Journal made these recommendations, with which I agree:

1. In an otherwise healthy young person, there is little cause for concern because the absolute risk of stroke is very low.

2. People with migraine who are on oral contraceptives have another reason for not smoking

3. Use low dose estrogen or progesterone only contraceptives in young women with migraine.

4. Although there isn’t much good evidence, many neurologists suggest stopping oral contraceptive pills if the migraine becomes more frequent or changes in character.

5. The risk of stroke gradually increases over age, particularly in smokers, so a slightly older smoking woman with migraine, should probably not be taking an oral contraceptive, unless it is the only option for her.

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Some Suggestions for Dealing with Insomnia

I have received an interesting question from a 50-year-old professional woman, who has had sleep problems that are especially severe during times of stress. As she says:
“I seem not to have the shut down switch in my brain.” She is worried about taking medications, and wonders if there is anything else that she can do to help herself.
____________________________

It is always unwise to make specific recommendations about someone without seeing them face-to-face, and the evaluation of a problem like this will normally take several hours. But the points that she raises have a great deal of relevance for so many people that I thought that a few comments would be helpful and equip everyone reading this with some information to discuss with their healthcare providers.

As usual, I think that it is a good idea to look at the question from the multiple dimensions of physical, psychological, social, subtle and spiritual. They are all inter-related, so dividing them up is simply a convenient way to help us think through the problem.

Before we do anything, we have to try and find out why someone has problems with sleep, and that may need investigations up to and including a sleep study.

The first thing is that my correspondent is female and likely either menopausal or perimenopausal. That is important, because as most women know, hormones have potent effects on sleep. It is not just that uncomfortable hot flashes can wake a person; it is also a direct effect of estrogen and probably of some of the releasing hormones in the hypothalamus. Hormone replacement therapy alone, does help some women but by no means all. Even at the physical level we see the general principle that there is rarely one cause for one problem. Typical menopausal sleep disturbances include a difficulty in falling asleep, and around 20% of menopausal women report that they sleep less than six hours a night. There is also some degradation in what we call sleep efficacy and an increase in deep slow wave sleep. Estrogen has effects on nasal mucosa, and when estrogen levels fall obstructive sleep apnea is more likely to occur. A major physical and psychological issue is that insomnia may become a learned habit that can persist even in the face of the best treatments.

This leads me to the second dimension, and that is psychological. The writer of the letter mentioned that she couldn’t turn off her thoughts. You would be amazed at how frequently I have been asked to consult on someone with a sleep problem and the individual has never been asked the question, “What is it that stops you falling asleep?” I have seen countless people prescribed sleeping tablets, when the real problem was anxiety or some other nasty problem that needed to be tackled first. In a moment I am going to make some suggestions that will try and help with both sleep and the ruminations and anxieties that may be contributing to its disturbance. Similarly, I have known a great many people whose sleep problems were the result of relationship difficulties or of something as simple as one person being a night owl and the other an early morning riser.

I always start with some simple sleep hygiene:

    1. Stress management
    2. Exercise a couple of hours before retiring
    3. Keeping mentally stimulated until it is time for bed
    4. Don’t go to bed until you are tired
    5. No caffeine, alcohol or nicotine after 6pm. (Preferably, of course, no nicotine ever!!) {Remember that many over the counter painkillers contain caffeine, as does chocolate}
    6. There are some specific dietary recommendations for helping with sleep, and I shall write about those on a future occasion
    7. Try to keep the bedroom atmosphere relaxing, and establish a sleep ritual
    8. If you cannot sleep, get up and do something relaxing: struggling to go to sleep is virtually impossible.
    9. Always get up at the same time in the morning, to try and re-set your brain, and as soon as you get up, be exposed to as much bright light as possible.
Now let me give you a few tricks that work on the five dimensions.
  1. Start by lying on your left side for 5-10 minutes and then roll onto your right side. This appears to work by exploiting the so-called nasal cycle, which I shall write more about on a future occasion.
  2. Still on the subject of the nose, one of the reasons that aromatherapy can be helpful, is because smell is unique amongst our senses, in that it is the only one that is not filtered by the thalamus. The regions of the brain that respond to smells are also directly related to some of the memory centers. The result is that smells can evoke memories extremely rapidly. You will probably have had the experience of smelling a perfume or cologne and instantly remembering someone who wore it in the past. This close linkage of smell and memory has enormous survival advantages: the smell of a predator can cause us to respond extremely rapidly. We can also use this knowledge to our advantage. Lavender has been used as a sleep aid for centuries. You can try putting a few drops of lavender oil on a cloth on your night-stand. Or you can use an electric diffuser or aromatherapy lamp. When I was growing up, we grew lavender and would put sprigs of it in the bed linens. It certainly seemed to help.
  3. Some people have found that melatonin can be very helpful, and it is readily available. Discuss it with your health care provider.
  4. Here is an old trick from traditional Chinese medicine. If you cannot sleep, soak a washcloth in cold water, lie down and put it on your abdomen for about ten minutes. I was taught that this works by pulling excess energy out of your head and neck down into the abdomen. There’s not a shred of scientific evidence that the technique works, but it does surprisingly often.
  5. If people who are good at visualization, some have reported great success by creating a picture of a warm, calm and relaxing place. And not just a picture, but also a five senses experience. It has to be personal, and perhaps even a place to go back to on a regular basis. When I first learned to do hypnotherapy I was put into a light trance by one of my teachers. To this day, more than 25 years later I can still vividly recall the experience of being told that I was drowsing on a grassy knoll on a warm summer’s day on the Downs of Southern England, and actually feeling that I was there. I can still evoke the memory at will and I’ve made it more detailed over time. If you are a visualizer, try that.
  6. Another technique that I learned from an early teacher, is to review the day backwards. Remembering what you did immediately before going to bed, and before that and so on. A simpler and often effective technique is just to start slowly counting backwards from 100.
  7. Herbs: There are three that are widely used, and for which there is some research base. There is good evidence that the herb Valerian can induce drowsiness, and it is widely used – even by doctors – in France and Germany. An important point about valerian is that it is poorly absorbed and chemically and thermally unstable. So it needs to be kept cool, and used fairly soon after it is prepared. As with all herbs, Valerian has side effects and can interact with prescription medications and alcohol, so it really is essential to discuss its use with your health care provider. The same goes for the other two widely used herbs: Hops and Passionflower.
  8. There is some evidence, though it’s not that strong, that taking a combined calcium/magnesium supplement (500mg calcium and 250-500mg magnesium) an hour before bed helps some people.
  9. I recommend massaging your facial muscles before lying down to sleep. Not only does this reduce muscle tension, but also the face is covered in acupuncture points, and so that may be another reason why it can help.
  10. Do not read or watch television in bed, but listen to a little calming music before retiring.

I do hope that will help you in your discussions with your health care provider. And I am always interested in hearing other suggestions, particularly if there is some research to back them up.

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Sleep and Mood

The interaction between sleep and mood is fascinating, complex and supremely practical.

I have received a couple of queries and comments. Let me start with one from a physician:

“I have a question about sleep disorders. My patients seem to suffer from this even after their depression is better.” 

This is an extremely interesting issue.

Every healthcare student has been taught about the sleep disturbances that may occur in association with mood disorders. The classic problems in depression are early morning wakening, difficulty in getting off to sleep and sometimes waking in the early hours. Some others will sleep for very long periods, and there has been speculation that this may be a form of hibernation behavior. People with abnormally elevated mood can often stay awake for days at a time. There is also the well-known problem of seasonal affective disorder, in which the long winter nights can cause depression. Fortunately the depression is often relieved by the use of a light box.

Many experts now consider that the disturbances of sleep are often the primary problem, which then cause depressed or elevated mood. This is actually not a new idea: one of the old fashioned treatments for depression was sleep deprivation and many of us who have worked all night have experienced the mildly manic symptoms of sleep deprivation. On early morning rounds at the hospital I commented that it was easy to tell if some of the residents had been working all night, even before they presented their reports. The giggling, high energy and disturbances in thought patterns were not at all what one sees when someone is tired.

It is not just the sleep deprivation, but also light. It is well known that people suffering with bipolar disorder are more likely to get manic episode in the spring and early summer, as the amount of ambient light increases. It is the converse of the seasonal affective disorder problem.

So what often happens is that antidepressant medications do indeed help with the depressed mood, but the underlying sleep problem takes much longer to correct itself. This is also one of the reasons why people who have seen their mood improve on treatment still have cognitive problems that can go on for months after the mood symptoms have been corrected. It is probably a combination of sleep deprivation and also the impact of corticosteroids that can rise in some sufferers causing transient damage to some key regions of the brain.

It would be nice if we could modulate people’s sleep/wake cycles and thereby treat the mood problems directly, but at the moment, despite the enormous advances in pharmacological treatments of sleep problems, we are still not able to do that reliably.

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