Richard G. Petty, MD

Hypnosis and Electrical Activity In the Brain

Following my post on Meditation and the Brain a perceptive reader just asked a great question:

“Has any of the research found any difference between hypnosis and meditation as it relates to brainwaves. And do people in a state of hypnosis demonstrate these high gamma waves?”

This is so interesting that I thought it was worth a short note of its own.

On the first occasion that I was hypnotized during my training, I remember thinking that the experience was very like the first stage of meditative practice: I was primarily using Vipassana back then. Subsequent subjective experiences have all tended to confirm that view: there are some similarities between trance and early meditative experiences.

There is a good amount of empirical research that tends to confirm that. John Gruzelier’s group at Imperial College in London has published some very fine work using not just electroencephalographic (EEG) measurements, but also functional MRI (fMRI). Gamma waves are between 30 to 100 Hertz, or cycles per second, and appear to reflect the way in which cells exchange information about the environment and form mental impressions. Gamma oscillations have a role in the subjective experience of pain. Not only has Gruzelier’s group shown some of the same gamma wave coherence, but also, research published in October of last year suggests that individual differences in hypnotic susceptibility are linked with the efficiency of the frontal lobe attention system. Hypnosis appears to involve a dissociation of the prefrontal cortex from other neural functions. Both the meditation and hypnosis studies have indicated that the key regions are primarily in the left frontal lobe.

The difference is that although people can demonstrate similar gamma wave activity when hypnotized, in the experienced meditators the gamma wave activity was there all the time, but would increase dramatically when meditating. How dramatic? Thirty fold higher activity than in a non-meditator. The trained brain is physically different from the untrained one.

Bob McCarley’s group at Harvard has done some interesting work in which healthy volunteers and people with schizophrenia were asked to look at images. The people suffering from schizophrenia showed no gamma wave activity at all.

Interestingly, there is also a very recent paper out in the Journal of Psychoactive Drugs showing the same EEG gamma coherence in two experienced people using the Brazilian drug ayahuasca, which suggest further similarities between meditation and shamanic psychedelic practices.

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Some Suggestions for Dealing with Insomnia

I have received an interesting question from a 50-year-old professional woman, who has had sleep problems that are especially severe during times of stress. As she says:
“I seem not to have the shut down switch in my brain.” She is worried about taking medications, and wonders if there is anything else that she can do to help herself.
____________________________

It is always unwise to make specific recommendations about someone without seeing them face-to-face, and the evaluation of a problem like this will normally take several hours. But the points that she raises have a great deal of relevance for so many people that I thought that a few comments would be helpful and equip everyone reading this with some information to discuss with their healthcare providers.

As usual, I think that it is a good idea to look at the question from the multiple dimensions of physical, psychological, social, subtle and spiritual. They are all inter-related, so dividing them up is simply a convenient way to help us think through the problem.

Before we do anything, we have to try and find out why someone has problems with sleep, and that may need investigations up to and including a sleep study.

The first thing is that my correspondent is female and likely either menopausal or perimenopausal. That is important, because as most women know, hormones have potent effects on sleep. It is not just that uncomfortable hot flashes can wake a person; it is also a direct effect of estrogen and probably of some of the releasing hormones in the hypothalamus. Hormone replacement therapy alone, does help some women but by no means all. Even at the physical level we see the general principle that there is rarely one cause for one problem. Typical menopausal sleep disturbances include a difficulty in falling asleep, and around 20% of menopausal women report that they sleep less than six hours a night. There is also some degradation in what we call sleep efficacy and an increase in deep slow wave sleep. Estrogen has effects on nasal mucosa, and when estrogen levels fall obstructive sleep apnea is more likely to occur. A major physical and psychological issue is that insomnia may become a learned habit that can persist even in the face of the best treatments.

This leads me to the second dimension, and that is psychological. The writer of the letter mentioned that she couldn’t turn off her thoughts. You would be amazed at how frequently I have been asked to consult on someone with a sleep problem and the individual has never been asked the question, “What is it that stops you falling asleep?” I have seen countless people prescribed sleeping tablets, when the real problem was anxiety or some other nasty problem that needed to be tackled first. In a moment I am going to make some suggestions that will try and help with both sleep and the ruminations and anxieties that may be contributing to its disturbance. Similarly, I have known a great many people whose sleep problems were the result of relationship difficulties or of something as simple as one person being a night owl and the other an early morning riser.

I always start with some simple sleep hygiene:

    1. Stress management
    2. Exercise a couple of hours before retiring
    3. Keeping mentally stimulated until it is time for bed
    4. Don’t go to bed until you are tired
    5. No caffeine, alcohol or nicotine after 6pm. (Preferably, of course, no nicotine ever!!) {Remember that many over the counter painkillers contain caffeine, as does chocolate}
    6. There are some specific dietary recommendations for helping with sleep, and I shall write about those on a future occasion
    7. Try to keep the bedroom atmosphere relaxing, and establish a sleep ritual
    8. If you cannot sleep, get up and do something relaxing: struggling to go to sleep is virtually impossible.
    9. Always get up at the same time in the morning, to try and re-set your brain, and as soon as you get up, be exposed to as much bright light as possible.
Now let me give you a few tricks that work on the five dimensions.
  1. Start by lying on your left side for 5-10 minutes and then roll onto your right side. This appears to work by exploiting the so-called nasal cycle, which I shall write more about on a future occasion.
  2. Still on the subject of the nose, one of the reasons that aromatherapy can be helpful, is because smell is unique amongst our senses, in that it is the only one that is not filtered by the thalamus. The regions of the brain that respond to smells are also directly related to some of the memory centers. The result is that smells can evoke memories extremely rapidly. You will probably have had the experience of smelling a perfume or cologne and instantly remembering someone who wore it in the past. This close linkage of smell and memory has enormous survival advantages: the smell of a predator can cause us to respond extremely rapidly. We can also use this knowledge to our advantage. Lavender has been used as a sleep aid for centuries. You can try putting a few drops of lavender oil on a cloth on your night-stand. Or you can use an electric diffuser or aromatherapy lamp. When I was growing up, we grew lavender and would put sprigs of it in the bed linens. It certainly seemed to help.
  3. Some people have found that melatonin can be very helpful, and it is readily available. Discuss it with your health care provider.
  4. Here is an old trick from traditional Chinese medicine. If you cannot sleep, soak a washcloth in cold water, lie down and put it on your abdomen for about ten minutes. I was taught that this works by pulling excess energy out of your head and neck down into the abdomen. There’s not a shred of scientific evidence that the technique works, but it does surprisingly often.
  5. If people who are good at visualization, some have reported great success by creating a picture of a warm, calm and relaxing place. And not just a picture, but also a five senses experience. It has to be personal, and perhaps even a place to go back to on a regular basis. When I first learned to do hypnotherapy I was put into a light trance by one of my teachers. To this day, more than 25 years later I can still vividly recall the experience of being told that I was drowsing on a grassy knoll on a warm summer’s day on the Downs of Southern England, and actually feeling that I was there. I can still evoke the memory at will and I’ve made it more detailed over time. If you are a visualizer, try that.
  6. Another technique that I learned from an early teacher, is to review the day backwards. Remembering what you did immediately before going to bed, and before that and so on. A simpler and often effective technique is just to start slowly counting backwards from 100.
  7. Herbs: There are three that are widely used, and for which there is some research base. There is good evidence that the herb Valerian can induce drowsiness, and it is widely used – even by doctors – in France and Germany. An important point about valerian is that it is poorly absorbed and chemically and thermally unstable. So it needs to be kept cool, and used fairly soon after it is prepared. As with all herbs, Valerian has side effects and can interact with prescription medications and alcohol, so it really is essential to discuss its use with your health care provider. The same goes for the other two widely used herbs: Hops and Passionflower.
  8. There is some evidence, though it’s not that strong, that taking a combined calcium/magnesium supplement (500mg calcium and 250-500mg magnesium) an hour before bed helps some people.
  9. I recommend massaging your facial muscles before lying down to sleep. Not only does this reduce muscle tension, but also the face is covered in acupuncture points, and so that may be another reason why it can help.
  10. Do not read or watch television in bed, but listen to a little calming music before retiring.

I do hope that will help you in your discussions with your health care provider. And I am always interested in hearing other suggestions, particularly if there is some research to back them up.

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Sleep and Mood

The interaction between sleep and mood is fascinating, complex and supremely practical.

I have received a couple of queries and comments. Let me start with one from a physician:

“I have a question about sleep disorders. My patients seem to suffer from this even after their depression is better.” 

This is an extremely interesting issue.

Every healthcare student has been taught about the sleep disturbances that may occur in association with mood disorders. The classic problems in depression are early morning wakening, difficulty in getting off to sleep and sometimes waking in the early hours. Some others will sleep for very long periods, and there has been speculation that this may be a form of hibernation behavior. People with abnormally elevated mood can often stay awake for days at a time. There is also the well-known problem of seasonal affective disorder, in which the long winter nights can cause depression. Fortunately the depression is often relieved by the use of a light box.

Many experts now consider that the disturbances of sleep are often the primary problem, which then cause depressed or elevated mood. This is actually not a new idea: one of the old fashioned treatments for depression was sleep deprivation and many of us who have worked all night have experienced the mildly manic symptoms of sleep deprivation. On early morning rounds at the hospital I commented that it was easy to tell if some of the residents had been working all night, even before they presented their reports. The giggling, high energy and disturbances in thought patterns were not at all what one sees when someone is tired.

It is not just the sleep deprivation, but also light. It is well known that people suffering with bipolar disorder are more likely to get manic episode in the spring and early summer, as the amount of ambient light increases. It is the converse of the seasonal affective disorder problem.

So what often happens is that antidepressant medications do indeed help with the depressed mood, but the underlying sleep problem takes much longer to correct itself. This is also one of the reasons why people who have seen their mood improve on treatment still have cognitive problems that can go on for months after the mood symptoms have been corrected. It is probably a combination of sleep deprivation and also the impact of corticosteroids that can rise in some sufferers causing transient damage to some key regions of the brain.

It would be nice if we could modulate people’s sleep/wake cycles and thereby treat the mood problems directly, but at the moment, despite the enormous advances in pharmacological treatments of sleep problems, we are still not able to do that reliably.

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Lupus Question

I had a very nice letter from a gentleman who posed the following question, which I have slightly edited in order to maintain confidentiality:

"A friend of mine, a 36 year old female has been diagnosed with Lupus.Healing by her doctors is not an option. Treatment yes. That’s not good enough. Any recommendations on how to heal it, who to see, what to read?"

It is always difficult for a health care practitioner to make precise recommendations about an individual whom they have not seen. That’s why we get so frustrated by some of the people who sell “cure alls” on their websites or infomercials. And when they are challenged say “but I’m not a doctor.” In which case, why are you giving advice??

Let me first say something about lupus. Systemic lupus erythematosus (SLE) is one of the so-called non-organ specific autoimmune diseases. What that means is that it can attack virtually any organ that has a DNA “command center.” And immune complexes can attack the skin, joints, kidneys, lymph nodes and so on. The autoimmune diseases show us how unwise it is for folk to advise us to “boost” our immune systems. SLE is an example of an overly boosted immune system. We should aim to balance our immune systems.

There is a lot of evidence that SLE has been becoming more common in recent years. Though we always have to be careful when we are told that an illness is becoming more common. That apparent increase may also be accounted for by other factors:

  1. More physicians may be becoming familiar with the illness: I saw this happen some years ago after I published an account of the first British case of a very rare type of headache. Within months, several other cases had been found. In each case doctors wrote to me saying that they had been treating the sufferer without success for many years, but after my report, understood what the problem had been, and, following my rules, had cured their patients.
  2. Diagnostic tests are becoming more sensitive, so more cases are turning up.
  3. Specialists are very good at changing the diagnostic criteria for an illness, or the level at which treatment is required: the “when is a difference a disease?” issue. Skeptics are forever saying that the only reason for doing so is so that drug companies can sell more drugs. But that’s a real misunderstanding: it’s actually the other way round. We change criteria once we have evidence that treatment may do some good. A good example is blood pressure. The levels at which we recommend treatment have been falling in recent years, because we now know that even minor hypertension can increase the risk of heart disease. Or diabetes mellitus, where the diagnostic blood sugar levels have been reduced for this reason: even small elevations of blood glucose increase the chance of damage to some blood vessels. It’s not the glucose itself that’s the problem, but the consequences of an elevated glucose level.

The reason for this preamble is this: if SLE is becoming more common, it is difficult to explain using conventional medical models. Some years ago, there was a report that more than half of all sufferers carried an organism called mycoplasma, and that this might be the cause of the illness. Nobody was ever able to replicate that finding, so the idea of an infectious cause is firmly on the back burner.

So let’s look at the illness from the perspective of physical, psychological, social, subtle and spiritual factors, for all come into play in someone dealing with SLE. The key to treatment is to have a healing synergy between all of the interlinked aspects of our lives.

On the physical front, conventional medicines have a great deal to offer, but as you said, for treatment rather than cure. They are also used to help protect organs against damage. One potential reason for the increase in the prevalence of SLE, is that there is a close link between the amount of fat in the abdomen and the production of some classes of inflammatory mediators. So question one: does the sufferer have an excess of intra-abdominal fat? If yes, diet and much gentle exercise as the illness will allow. What kind of a diet? Balanced, and following the principles which I outlined in the final part of the Healing, Meaning and Purpose.

There have been countless reports of people with SLE and other forms of inflammatory arthritis, especially rheumatoid, having food sensitivities particularly to dairy or to alfalfa. The research base is weak, but it is always worth exploring. There has been growing interest in the use of DHEA and foods high in omega-3 fatty acids. Some people have also reported some benefit from Vitamins C and E, and selenium. The treating physician can help with doses. There are also some herbal and homeopathic remedies that may be helpful. I quite like The Arthritis Bible by Craig Weatherby and Leonid Gordin as an overview of some of these approaches.

Next is psychological. Sunlight, stress, fatigue and lack of sleep can all make the condition worse, and I would urge the person to follow some of the plans that I outline on the CDs and in the book. An awful lot of people suffer from illnesses like this as a consequence of psychological factors. So it is a really good idea to use the approaches to see if there are any emotional, cognitive or relationship problems which have triggered or are perpetuating the autoimmune process.

Next is the subtle systems that underlie the physical and psychological. These may need to be re-programmed using acupuncture, or Reiki, or Thought Field therapy, or even high potency homeopathic remedies.

Finally the spiritual. I cannot over-emphasize the importance of this in all our lives. Again, I have made some suggestions in the program. It would not be right for me to tell others what or how to practice, but keeping in touch with, and strengthening the contact with your spiritual essence provides a wellspring of healing energy and support.

There is a final point that I would like to make. Not all illnesses can be made to disappear, and sometimes our focus has to change to one of helping the individual understand, learn from and coexist with the illness.

Who to see? Any health care professional that will respect all five domains, and help the individual to help themselves.

Now, back to you: does that help?

+ Are there others out there who would like to share their experiences?

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